Current Study: A4

Purpose:

• The overall purpose for this study is to find out if the investigational study drug is absorbed or eliminated differently in people with normal liver function compared to people with impaired liver function. Another purpose is to assess the safety and tolerability of the study medication in people with healthy to impaired liver function.
• This study is for research purposes only and is not intended to treat your liver disease.

Method of Administration: Single subcutaneous injection

Investigator Thomas Marbury, MD

To qualify:

• 18 years to 75 years old
• Must have decreased liver function or disease such as fatty liver disease (NASH), Hepatitis C, past history of alcohol related liver disease or cirrhosis
• Volunteers may be taking medicines such as spironolactone (Aldactone®), furosemide (Lasix®), lactulose, or rifaximin (Xifaxan®)
• May also have ascites (fluid in your abdomen) or encephalopathy (brain condition that causes irritability or trouble sleeping)

Study details:
• 1 eligibility screening visit
• 9 consecutive days and 8 nights in our research facility
• 8 follow-up visits

Qualified participants will receive study medication, study related physical exams and laboratory tests

Location 5055 South Orange Avenue, Orlando, FL 32809

Compensation Qualified participants will be compensated up to $6,500 for study-related time and procedures

Whom to Contact Recruitment Department: 407-240-7876