Current Study: P 9

Purpose:
• The overall purpose for this study is to find out if the study drug is absorbed or eliminated differently in individuals with normal liver function compared to individuals with varying degrees of impaired liver function. Another purpose is to assess the safety and tolerability of the drug in people with healthy to impaired liver function.
• This study is for research purposes only and is not intended to treat your liver disease.

Method of Administration: Single injection of study drug just beneath the skin of the abdomen

Investigator: Thomas Marbury, MD

To qualify:
• Between the ages of 18 to 75 years old
• Must have decreased liver function or disease such as fatty liver disease (NASH), Hepatitis C, past history of alcohol related liver disease or cirrhosis
• Volunteers may be taking medicines such as spironolactone (Aldactone®), furosemide (Lasix®), lactulose, or rifaximin (Xifaxan®)
• May also have ascites (fluid in your abdomen) or encephalopathy (brain condition that causes irritability or trouble sleeping)

Length/Duration:
• 9 days and 8 nights in our research facility
• 5 follow-up visits

Location: 5055 South Orange Avenue, Orlando, FL 32809

Compensation:
Qualified participants will receive study medication, study related physical exams and laboratory tests

Qualified participants will be compensated up to $5,600 for time and travel

Whom to Contact: Recruitment Department at 407-240-7876