Current Study: N6

Purpose:

• The overall purpose for this study is to find out if the investigational study drug is absorbed or eliminated differently in participants with normal liver function compared to participants with impaired liver function. Another purpose is to assess the safety and tolerability of the study drug in people with healthy to impaired liver function.
• This study is for research purposes only and is not intended to treat your liver disease.

Method of Administration: Single oral dose of study drug

Investigator: Thomas Marbury, MD

To qualify:

• 18 to 80 years old
• Must have decreased liver function or disease such as fatty liver disease (NASH), history of Hepatitis C, past history of alcohol related liver disease or cirrhosis
• Volunteers may be taking medicines such as spironolactone (Aldactone®), furosemide (Lasix®), lactulose, or rifaximin (Xifaxan®)
• May also have ascites (fluid in your abdomen) or encephalopathy (brain condition that causes irritability or trouble sleeping)

Length/Duration:
• 1 eligibility screening visit
• 16 consecutive days and 15 nights in our research facility
• 1 follow-up visit

Location: 5055 South Orange Avenue, Orlando, FL 32809

Compensation Qualified participants will receive study medication, study related physical exams and laboratory tests

Qualified participants will be compensated up to $7,400 for time and travel

Whom to Contact Recruitment Department: 407-240-7876