Current Study: T8

Purpose:
• To find out if the study drug is absorbed or eliminated differently in participants with normal liver function compared to participants with liver impairment (decreased liver function). Information regarding safety and side effects that may occur will also be collected
• This study is for research purposes only and is not intended to treat your liver disease

Method of Administration: Single oral dose of study drug

Investigator: Thomas Marbury, MD

To qualify:
• At least 18 years old
• Must have decreased liver function or disease such as fatty liver disease (NASH), history of Hepatitis C, past history of alcohol related liver disease or cirrhosis
• Volunteers may be taking medicines such as spironolactone (Aldactone®), furosemide (Lasix®), lactulose, or rifaximin (Xifaxan®)
• May also have ascites (fluid in your abdomen) or encephalopathy (brain condition that causes irritability or trouble sleeping)

Length/Duration:
• 4 consecutive days and 3 nights in our research facility
• 1 follow-up phone call

Qualified participants will receive study medication, study related physical exams and laboratory tests

Compensation: Qualified study participants will be compensated up to $2,000 for time and travel

Location: 5055 South Orange Avenue, Orlando, FL 32809

Whom to Contact
Recruitment Department: 407-240-7876